News

2019-2020 Abrams Scholars

Congratulations to AJ, Joella, and Aituaje, who were both selected as Abrams scholars for the 2019-2020 academic year.

 

AJ will be continuing on his independent research project:

Comparison of grafts for adolescent ACL reconstruction: Adolescent anterior cruciate ligament (ACL) injuries are becoming more common in recent years due to an increase in adolescents’ sports participation. The type of ACL reconstruction surgery that is appropriate for each injury depends on multiple variables, including age, severity of damage, and the surgeon’s preference. One common treatment approach involves removing the damaged ACL and replacing it with a surgical graft. Comparison studies have been conducted for adult populations receiving surgical grafts, however there is a lack of available data adolescent populations. This project involves developing a testing protocol to measure viscoelastic properties of grafts in a physiological environment. Once a protocol has been established, a graft comparison study using a growing porcine model will be conducted. The study will test the mechanical differences between various grafts at different ages (for example, hamstring tendons, bone-patella tendon-bone, etc.) to better choose which graft may be most appropriate in the adolescent population.

 

Aituaje will continue working with Zack on a project that she began over the summer:

Effect of material and 3D printing parameters on replicating the structure and mechanical properties of the meniscus: The meniscus is a load-bearing tissue in the knee with complex geometry. Treatment of injuries to the meniscus often lack patient-specific size matching. Fused Deposition Modelling (FDM) is a 3D printing technique that melts a thermoplastic then extrudes it in the form of small fibers in a layer by layer manner. This allows us to create complex shapes controlled by computer-guided code. This project aims to apply FDM as a tool to replicate patient-specific geometries, assessed from MRI scans, while matching the meniscus’s mechanical properties by varying materials and printing parameters. The student will perform tensile and compressive testing on 3D printed samples to analyze their mechanical properties.

 

And Joella will continue working with Danielle:

Characterizing the microstructure of the ACL throughout skeletal growth: 
The anterior cruciate ligament (ACL) connects the femur to the tibia, and functions as a major stabilizer in the knee joint. Injury and surgical reconstruction of the ACL in pediatric patients are rapidly increasing, but these surgeries result in 4-6 times higher secondary injury rates compared to these surgeries in adults. Further, females are at a much higher risk of ACL tear than males during adolescence but not childhood or adulthood. The ligament is largely hypocellular and is composed mainly of aligned collagen, but little data is available regarding its specific microstructure throughout growth. This project will aim to histologically examine the microstructural properties of the ACL in males and females throughout skeletal growth. Results from this project will help us understand what might contribute to the disparity in injury rates between males and females throughout growth. Further, this data can be applied to help inform the development of sex- and age-specific tissue engineered ligaments.

 

 

 

About the Abrams Scholars Program:

Abrams Scholars are outstanding BME undergraduate students who are selected to receive a stipend to conduct hands-on laboratory research projects. These projects are conceived and designed by the students with the guidance of a faculty mentor. The Abrams Scholar program honors C. Frank Abrams, Jr., a BME and BAE emeritus faculty member. Dr. Abrams led the development of the first courses in Biomedical Engineering at NC State and was instrumental in the founding of NC State’s BME Department, the creation of the joint UNC-CH/NC State graduate program, and ultimately the launch of the UNC-CH/NC State Joint BME Department. He was the Joint Department’s first senior design instructor as well as the first Director of Graduate Studies.

Stephanie Cone’s Last Day

We recently dedicated a lab meeting to celebrating Stephanie and Paul and their accomplishments. We’re so proud of the lab’s very first PhD students!

 

We started with a review of the 2+ year-long study that they’ve been conducting: A retrospective of Paul’s man-bun.

 

Matt presented them with gifts wrapped in their very first posters (or the earliest we could find):

 

Personalized jerseys! (Size youth extra small, for for display rather than wearing). Matt also had all of their lab mates sign a photo mat that went in the frame.

 

Congratulations to our Graduates!

Graduation 2019 was an exciting day for the lab. We graduated our first two Ph.D students: Stephanie and Paul. We also had three undergrads graduate this year: Emily, who joined our lab four years ago as a freshman, as well as Alex and Raghad, who joined us last summer.

 

Stephanie will be going on to a post-doc in at the University of Wisconsin at Madison. Emily is going on to grad school at the University of Delaware. Alex and Raghad have both gotten great jobs in industry here in RTP.

 

 

 

 

 

Congratulations graduates!

 

 

Fourth Annual Mini Golf Competition (aka we’re getting tired of this Matt!)

In a shocking turn of events, Matt won at mini golf once again, and made sure to rub in his 4-peat. You’re the best at mini golf, we get it, SHEESH. He was bequeathed the 2019 mini golf trophy, which he will lord over the rest of us for at least a few months.

 

In a new twist, we had a tie for last place – Paul and Zack get joint custody of the much coveted losers trophy. Great job guys!

 

Matt adds to his trophy collection

 

 

 

They were clearly thrilled to be sharing last place

 

Novozymes SciMatch (formerly Invite a Scientist) visit

We once again visited Ms. Baumgarten’s class at Apex Middle School. Unlike last time, Ms Baumgarten is now teaching 8th grade science, which means they know about cells/tissues, so we decided to make them honorary doctors and brainstorm how to treat some knee injuries. (we think) they had a great time and we know we did!

 

See Steph’s tweet here and below:

 

TORL Participates in National Biomechanics Day

We joined forces with many other labs in the College of Engineering to once again put on an amazing National Biomechanics Day! We had about 150 students from around the triangle come to learn about engineering, biomechanics, and why NC State (and BME especially) is awesome. Check out some photos below.

 

Emily and Danielle model tissue growth with expanding sponges

Zack shows some visitors how we use the 3D printer as part of our research

 

BFFs! Aren’t they adorable??

 

Stephanie C and Danielle show some students how we use 3D imaging to assess knee injuries.

Outreach with Exploris Elementary

Late last year, we were contacted by a local teacher, Annah Riedel, at Exploris Elementary School. She met us at SciREN and wanted to pair up to teach her fourth graders a bit about 3D printing and introduce them to the Engineering Design Process. First, they came to us out at the vet school and we showed them three different approaches to 3D printing. Then, they were each given a challenge to be solved by designing something and drafting a prototype to 3D print in TinkerCad. We met with them a few times to give design feedback, then picked a winner from each group to actually print.

 

Everyone had a great time (at least we hope) and everyone learned a lot, especially us! Thanks so much Annah for reaching out. You can read her blog post about it here.