Lewis Gaffney

Lewis Gaffney, B.S.

Graduate Student Researcher
Joint Department of Biomedical Engineering
North Carolina State University & University of North Carolina-Chapel Hill



Lewis began his PhD career in August of 2015 after completing his undergraduate degree in western North Carolina. Lewis’ research focuses primarily on developing a model for interactions of the muscle tendon unit to guide scaffold development and regenerative medicine therapies. In his spare time Lewis loves riding and racing his bike, listening to the Avett Brothers and Taco Tuesday.

B.S. Mathematics, Brevard College, 2014

B.S. Exercise Science, Brevard College, 2014


2019 BME Department Travel Award

2015 TORL Lab Rookie of the Year

2014 Highest GPA for Exercise Science Majors

2014 Outstanding Student for Mathematics Majors

2012 ACA STEM Scholarship Recipient


Badileanu, A., Mora-Navarro, C., Gracioso Martins, A.M., Sze, D., Ozpinar, E.W., Gaffney, L., Enders, J.R., Branski, R.C., Freytes, D.O., Fast Automated Approach for the Derivation of Acellular Extracellular Matrix Scaffolds from Porcine Soft Tissues. ACS Biomaterials Science & Engineering, 6(7) 4200-4213


Mora-Navarro, C., Badileanu, A., Gacioso Martins, A. M., Ozpinar, E. W., Gaffney, L., Huntress, I., Harrell, E., Enders, J. R. Peng, X., Branski, R. C., Freytes, D. O., (2020) Porcine Vocal Fold Lamina Propria-Derived Biomaterials Modulate TGF-B1-Mediated Fibroblast Activation in vitro. ACS Biomaterials Science & Engineering, 6(3) 1690-1703


Chang, Y.J., Duffy, D.J., Gaffney, L., Fisher, M.B., Moore, G.E., Assessment of Skin Staples for Augmentation of Core Tenorrhaphy in an ex vivo Model of Canine Superficial Digital Flexor Tendon Laceration. American Journal of Veterinary Research, 81(8), 681-688


Duffy, D.J., Curcillo, C.P., Chang, Y.J., Gaffney, L., Fisher, M.B., Moore, G.E. (2020) Biomechanics Evaluation of an Autologous Flexor Digitorum Lateralis Graft to Augment the Surgical Repair of Gastrocnemius Tendon Laceration in a Canine ex vivo Model. Veterinary Surgery, 1-10


Duffy, D.J., Chang, Y-J., Gaffney, L., Fisher, M.B., Moore, G.E. (2019) Effect of Bite Depth of an Epitendinous Suture on the Biomechanical Strength of Repaired Canine Flexor Tendons. American Journal of Veterinary Research, 80 (11), 1043-1049


Nandi, S., Sproul, E. P., Nellenbach, K., Erb, M., Gaffney, L., Freytes, D. O., & Brown, A. C. (2019). Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes. Biomaterials Science, 7(2), 669-682.


Gaffney, L., Warren, P., Wrona, E. A., Fisher, M. B., & Freytes, D. O. (2017). Macrophages’ role in tissue disease and regeneration. In Macrophages (pp. 245-271). Springer, Cham.


Gaffney, L., Wrona, E. A., & Freytes, D. O. (2017). Potential synergistic effects of stem cells and extracellular matrix scaffolds. ACS Biomaterials Science & Engineering, 4(4), 1208-1222.




Gaffney, L., Fisher, M., & Freytes, D. Muscle and Tendon Derived Extracellular Matrix Promotes Expression of Myotendinous Junction specific Integrins in Myoblast Cell Culture. Summer Biomechanics, Bioengineering, Biotransport Conference. June 2019. Poster Presentation.
Gaffney, L., Fisher, M., & Freytes, D. Integrated Hydrogel Culture System for Co-Culture of Muscle & Tendon Cells for In vitro Modeling of Myotendinous Junction. Termis-AM, Charlotte NC. December 2017. Poster Presentation.
Gaffney, L., Fisher, M., & Freytes, D. Adjacent Hydrogel Culture System for Co-Culture of Muscle-Tendon cells for in vitro modeling of the Myotendinous Junction. NC State Biomaterial’s Day. Raleigh NC, 2017. Podium Presentation.
Gaffney, L., E.A. Wrona, P. Erb, A. Young, M.A. Daniele PhD, M.B. Fisher PhD, D.O. Freytes PhD. BioEngineered Muscle Tissue as a Functional Testing Platform for Inflammatory Responses and Effects of Extracellular Matrix Scaffold. North Carolina Tissue Engineering and Regenerative Medicine Society Annual Meeting, Chapel Hill, NC. 27, October 2016. Poster Presentation.