Understanding Post-Natal Musculoskeletal Soft Tissue Growth in the Porcine Model
The anterior cruciate ligament (ACL) is a primary soft tissue stabilizer of the knee. ACL injuries are rising in children and adolescents, with many undergoing surgical treatment. Yet, changes within the ACL during growth, including biomechanical properties, are less understood. Our work over the past decade has attempted to fill this knowledge gap. We have studied how age and sex impact the size and function of the ACL and its distinct sub-regions using a large animal model. We have also explored the impact of complete and partial injuries on resulting joint remodeling. More recent work has focused on evaluation of surgical reconstruction techniques in the pediatric joint and the role of hormones on region-specific changes in the ACL during growth. As we continue to translate our findings to the human condition, we hope to inform clinical treatment strategies in the pediatric population.
Funding Sources: National Institutes of Health, UNC Translational and Clinical Sciences Institute, UNC Thurston Arthritis Research Center, NC State University Comparative Medicine Institute
Advanced Scaffold Fabrication for FIBROUS SOFT TISSUE ENGINEERING
This research area focuses on applying engineering principles to study the use of 3D scaffold fabrication to create fibrous soft tissue replacements. Techniques include 3D printing, near-field, direct-write electrospinning, and melt blowing. Projects include tendon-on-chip and muscle-tendon junction model systems, scalable production of fibrous scaffolds for meniscus tissue engineering, and translational animal model systems for in-vivo evaluation.
Funding Sources: National Institutes of Health, NC State University Game-Changing Research Incentive Program, Orthopaedic Research and Education Foundation, National Stem Cell Foundation